Find more information on the Altmetric Attention Score and how the score is calculated. Due to strong electric fields at the surface, the absorption and scattering of electromagnetic radiation by noble metal nanoparticles are strongly enhanced. These unique properties provide the potential of designing novel optically active reagents for simultaneous molecular imaging and photothermal cancer therapy.
It is desirable to use agents that are active in the near-infrared NIR region of the radiation spectrum to minimize the light extinction by intrinsic chromophores in native tissue. In the present work, we provide an in vitro demonstration of gold nanorods as novel contrast agents for both molecular imaging and photothermal cancer therapy. Nanorods are synthesized and conjugated to anti-epidermal growth factor receptor anti-EGFR monoclonal antibodies and incubated in cell cultures with a nonmalignant epithelial cell line HaCat and two malignant oral epithelial cell lines HOC clone 8 and HSC 3.
The anti-EGFR antibody-conjugated nanorods bind specifically to the surface of the malignant-type cells with a much higher affinity due to the overexpressed EGFR on the cytoplasmic membrane of the malignant cells.
Cause of rare, fatal disorder in young children pinpointed Mark Sands and his colleagues have discovered the precise biochemical pathway leading to Krabbe disease, a fatal genetic disorder in children that results in seizures, developmental regression and death, usually around age 3. Mark Sands.
Matt Walter. Tim Ley. Half-century of research illuminates how cells work in health, disease More than 50 years ago, Stuart Kornfeld , was awarded his first research grant. Stuart Kornfeld. Fighting pancreatic cancer with immunotherapy In collaboration with investigators at Rush University in Chicago, David DeNardo and colleagues have found a chemical compound that promotes a vigorous immune assault against pancreatic cancer in mice.
David DeNardo. Li Ding. Riney boosts multiple myeloma research Their gift establishes the Paula C. Siteman Cancer Center. Dan Link. Relapsed leukemia flies under immune system's radar A study led by Matthew Christopher , Allegra Petti , Michael Rettig and Timothy Ley offers a potential explanation for why many AML patients experience a relapse after a stem cell transplant and suggests a therapeutic approach that may help to place relapsed patients back into remission.
Matt Christopher. New clues found to understanding relapse in breast cancer A large genomic analysis led by Obi Griffith in the Division of Oncology and The McDonnell Genome Institute has linked certain DNA mutations to a high risk of relapse in estrogen receptor positive breast cancer. Obi Griffith. Chris Maher. Personalized vaccine may extend survival of glioblastoma patients A multicenter clinical trial of a personalized vaccine has indicated improved survival rates in glioblastoma patients.
Jian Campian. Ron Bose Cynthia Ma. Experimental arthritis drug prevents stem cell transplant complication An investigational drug in clinical trials for rheumatoid arthritis prevents a common, life-threatening side effect of stem cell transplants, new research from Jaebok Choi , John DiPersio and colleagues. Jaebok Choi John DiPersio. Major milestone reached in effort to identify the genetic roots of cancer Researchers nationwide have reached a major milestone in describing the genetic landscape of cancer. Academy of Science-St. Louis honors Stuart Kornfeld Stuart Kornfeld was honored on April 5 at a dinner at the Missouri Botanical Garden in recognition of his outstanding scientific contributions.
Zika virus kills brain cancer stem cells While Zika virus causes devastating damage to the brains of developing fetuses, it one day may be an effective treatment for glioblastoma, a deadly form of brain cancer.
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Milan Chheda. John DiPersio. Chemo-loaded nanoparticles target breast cancer that has spread to bone Seeking new treatments for metastatic breast cancer, Kathy Weilbaecher and colleagues have designed nanoparticles that carry chemotherapy and are targeted directly to tumors that have spread to bone.
Kathy Weilbaecher. CRISPR sheds light on rare pediatric bone marrow failure syndrome Children with dyskeratosis congenita - characterized by short telomeres - experience progressive bone marrow failure, eventually losing the ability to make red blood cells, white blood cells and platelets. Luis Batista Chris Sturgeon. Rogue breast tumor proteins point to potential drug therapies Studying mice with breast tumors transplanted from patients, a group at Washington University led by Li Ding , in collaboration with colleagues at The Broad Institute of MIT and Harvard and Baylor College of Medicine, have analyzed the proteins present in these tumors.
Online database aims to collect, organize research on cancer mutations A group led by Obi and Malachi Griffith has developed an online "knowledgebase" to gather and organize information on cancer genomics, providing an educational forum for dissemination of information and discussion of the clinical significance of cancer genome alterations. Obi Griffith Malachi Griffith. Study unveils new way to starve tumors to death Many sarcomas lack an enzyme required for production of arginine, an essential component of most proteins, but attempts to kill the tumor cells by starving them of this nutrient have been unsuccessful.
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Brian Van Tine Jason Held. In highly lethal type of leukemia, cancer gene predicts treatment response Patients with the most lethal form of acute myeloid leukemia AML — based on genetic profiles of their cancers — typically survive for only four to six months after diagnosis, even with aggressive chemotherapy. John Welch. New immunotherapy for leukemia shows promise in small clinical trial A new type of immunotherapy shows promise against cases of acute myeloid leukemia AML that recur after treatment or that never respond to therapy in the first place.
Study finds marker of aggressive prostate cancer The level of an RNA molecule PCAT expressed in prostate tumors is an indicator of whether the cancer is likely to spread, according to research published by Chris Maher and colleagues. Bob Barczewski. Wilson Fok Alexandre Vessoni. Study seeks clues to breast cancer outcomes in African-American women Foluso Ademuyiwa and her colleague Laura Beirut Department of Psychiatry are launching a major study in African-American women with breast cancer to learn whether their genetic risks are influenced by the same mutations that affect white women or are altogether different mutations.
Foluso Ademuyiwa. Immune-based therapy in mice shows promise against pancreatic cancer David DeNardo , Andrea Wang-Gillam and their colleagues have shown that immunotherapy against pancreatic cancer can be effective when given in conjunction with focal adhesion kinase FAK inhibitors, drugs that break up the fibrous tissue in these tumors.
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Ramaswamy Govindan. Study uncovers hard-to-detect cancer mutations Li Ding and co-workers developed a software tool for finding a certain type of genetic error that has been consistently missed by cancer genome studies. Hematology-oncology faculty members receive scholar awards Luis Batista and Grant Challen have received V Scholar Grants from the V Foundation for Cancer Research to support their work on telomerase RNA in dyskeratosis congenita and novel tumor supressors in chronic myeloid neoplasms.
Relapse in AML is linked to genetic mutations that persist in remission Using genetic profiling to study bone marrow samples from patients with acute myeloid leukemia AML , Tim Ley and colleagues found that those whose cells still carried mutations 30 days after the initiation of chemotherapy were about three times more likely to relapse and die than patients whose bone marrow was cleared of these mutations.
New technology may reduce deadly complication of bone marrow transplants Linda Eissenberg , John DiPersio , and their colleagues have developed a new approach to mitigate graft-versus-host disease. Linda Eissenberg John DiPersio. Scot Hickman Jason Weber.
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Genetic errors linked to aging underlie leukemia that develops after cancer treatment Terrence Wong , a hematology-oncology fellow working in Dan Link's laboratory, found that mutations that accumulate randomly as a person ages can play a role in a fatal form of leukemia that develops after treatment for another cancer. Terrence Wong. Many older people have mutations linked to leukemia or lymphoma in their blood cells Analyzing blood samples from subjects enrolled in The Cancer Genome Atlas project, Li Ding and co-workers discovered that 5 percent of people over age 70 harbor mutations linked to leukemia and lymphoma.
Steve Oh. Some aggressive cancers may respond to anti-inflammatory drugs Jason Weber's laboratory has found that triple-negative breast cancer cells lacking the tumor suppressor proteins p53 and ARF turn on a JAK-dependent pathway involved in the innate immune response to viral infection. Jason Weber. New center aims to use immune system to fight cancer, other diseases A laboratory within the Center for Human Immunology and Immunotherapy Programs CHiiPs will monitor changes in the immune system during clinical trials of new immunotherapies.
Journal honors breast cancer researcher The Journal of Biological Chemistry has recognized Ron Bose and his colleagues for their work describing the combined structure of two proteins HER2 and HER3 that, when bound together, drive growth of many breast cancers. Ron Bose. Surprising culprit found in cell recycling defect Members of Stuart Kornfeld's laboratory have identified an unusual cause of the lysosomal storage disorder called mucolipidosis III.
Lee Ratner named Wolff Professor of Oncology Lee Ratner's primary research interest focuses on retroviruses, including the human T-cell leukemia virus type 1, which causes a specific form of lymphoma, and the human immunodeficiency virus HIV associated with AIDS.
Lee Ratner. Evan Sadler elected to the Institute of Medicine Evan Sadler , chief of the Division of Hematology, has been elected to the Institute of Medicine of the National Academy of Sciences, one of the highest honors medical scientists in the United States can receive. Evan Sadler. Genetic errors identified in 12 major cancer types Li Ding and co-workers have identified repeatedly mutated genes that appear to drive the development and progression of a range of tumors.
Database of disease genes shows potential drug therapies Obi Griffith and his twin brother Malachi, working with colleagues at The Genome Institute , have created an online database that matches genes linked to cancer and other diseases with drugs that target those genes. Discovery helps show how breast cancer spreads Working in mouse models of breast cancer and breast tumor samples from patients, Greg Longmore and his colleagues showed that a protein on the surface of tumor cells, called DDR2, binds to collagen and activates a multistep pathway that encourages tumor cells to spread.
nafunmelusy.ga Greg Longmore. Distinct niches in bone marrow nurture blood stem cells In research that one day could improve the success of stem cell transplants and chemotherapy, Dan Link and co-workers have found that distinct niches exist in bone marrow to nurture different types of blood stem cells. October George J.
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